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  • Title: Development of potent and selective dipeptidyl peptidase II inhibitors.
    Author: Senten K, Van der Veken P, Bal G, De Meester I, Lambeir AM, Scharpé S, Bauvois B, Haemers A, Augustyns K.
    Journal: Bioorg Med Chem Lett; 2002 Oct 21; 12(20):2825-8. PubMed ID: 12270155.
    Abstract:
    Structure-activity investigations of product-like dipeptide analogues lacking the C-terminal carbonyl function resulted in potent and selective dipeptidyl peptidase II (DPP II) inhibitors. Dab-Pip has an IC(50)=0.13 microM for DPP II and a 7600-fold selectivity with respect to DPP IV. This compound will be highly valuable for the investigation of the biochemical function of DPP II.
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