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  • Title: Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids.
    Author: Han S, Hamel E, Bastow KF, McPhail AT, Brossi A, Lee KH.
    Journal: Bioorg Med Chem Lett; 2002 Oct 21; 12(20):2851-3. PubMed ID: 12270161.
    Abstract:
    N-Acetylcolchinol methyl ether 1 served as the starting material to prepare the chloroacetamide (3) and epoxide (5) analogues. Both 3 and 5 were potent inhibitors of tubulin polymerization in vitro. Compound 3 was also 4-fold more cytotoxic than colchicine against the 1A9 tumor cell line and showed a unique cross-resistance profile.
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