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  • Title: Steroid receptors in Streptomyces hydrogenans: isolation and characterization of a high affinity receptor for 5alpha-dihydrotestosterone.
    Author: Kurth J, Träger L.
    Journal: Acta Microbiol Acad Sci Hung; 1975; 22(4):497-502. PubMed ID: 1227251.
    Abstract:
    There are different steroid binding receptors in the cytosol of Streptomyces hydrogenans. A high molecular weight component binds 5alpha-dihydrotestosterone (17beta-hydroxy-5alphaH-androstan-3-one) with high affinity. Partial purification is achieved by density gradient centrifugation and filtration on Sephadex G-200. 5alpha-Dihydrotestosterone and progesterone compete for the same binding sites on the receptor. Cyproterone and testosterone are not bound. As it is easy to isolate the binding fraction, a simple assay for 5alpha-dihydrotestosterone or progesterone in biological samples is available.
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