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  • Title: [Myelopathy and macrocytic anemia associated with a folate deficiency. Cure by folic acid].
    Author: Raphael JC, Choutet P, Barois A, Nouailhat F, Goulon M.
    Journal: Ann Med Interne (Paris); 1975 May; 126(5):339-48. PubMed ID: 1227361.
    Abstract:
    The authors report a case of myelopathy associated with macrotic anemia. The prior inefficacy of treatment with B1, B6 and B12 vitamins, in spite of a normal Schilling test, suggested the possibility of folate deficiency, the concentration of which was found very low in the serum (1.5 mg/ml). The addition of folic acid to the vitamins already administered without success, was followed by rapid recovery of the anemia and a frank neurological improvement maintained after 10 months follow-up. The rare similar cases observed in the world literature are analysed here. The other neurological manifestations, due to folate deficiency, the etiological circumstances and the methods of diagnosis are recalled.
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