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  • Title: Luteal 20alpha-hydroxy steroid dehydrogenase and the formation of delta4-3-oxo steroids in the rat after weaning or treatment with 2-bromo-alpha-ergocryptine during lactation.
    Author: Rodway RG, Kuhn NJ.
    Journal: Biochem J; 1975 Dec; 152(3):445-8. PubMed ID: 1227499.
    Abstract:
    Natural or early weaning of rat litters caused an increased activity of maternal luteal 20alpha-hydroxy steroid dehydrogenase and a decreased release of delta4-3-oxo steroids in vitro. 2. Compound CB-154 (2-bromo-alpha-ergocryptine) caused an increase of 20alpha-hydroxy steroid dehydrogenase activity in mid-lactation but not in early lactation. 3. Prolaction did not prevent these increases in enzyme activity. Luteal 20alpha-hydroxysteroid dehydrogenase and the formation of delta-4-3-oxo steroids after weaning, and treatment with 2-bromo-alpha-ergocryptine during lactation were investigated in the rat. Maternal luteal 20alpha-hydroxy steroid dehydrogenase activity on Day 10 of lactation was greatly increased when the litter had been removed 0-3 days before. In contrast, a decrease in the release of delta-4-3 oxo steroids in vitro was seen with early removal of the litter. The increase in 20alpha-hydroxy steroid dehydrogenase activity due to litter removal was not prevented by the simultaneous injection of prolactin. 2-broma-alpha-ergocryptine caused an increase of 20alpha-hydroxysteroid dehydrogenase activity in midlactation but not in early lactation. Prolactin did not prevent the increase. It is suggested that luteotrophin could possibly account for the enzyme induction after weaning.
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