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  • Title: [ The effect of prostaglandin E1 and noradrenaline on the tone of cerebral vessels and arterial pressure].
    Author: Mirzoian SA, Gabrielian ES, Amroian EA.
    Journal: Biull Eksp Biol Med; 1975 May; 79(5):75-7. PubMed ID: 1227598.
    Abstract:
    Acute experiments were conducted on cats; it was found that prostaglandine (PG) E1 produced a contrary effect on the tone of the cerebral vessels and on systemic arterial pressure depending on the presence of ethanol in its solution. Blocking of PG biosynthesis with indometacine promoted a marked increase in the vasoconstrictor reaction of the cerebral vessels and aided elevation of arterial pressure in response to noradrenaline administration. It is supposed that disturbance of PG biosynthesis in the organism could play a definite role in the genesis of hypertension and cerebrovascular disturbances.
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