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  • Title: [Radioprotective effect of pyrazolone derivatives].
    Author: Piskarev AV, Nesterenko VS.
    Journal: Biull Eksp Biol Med; 1975 Jul; 80(7):58-60. PubMed ID: 1227650.
    Abstract:
    The intraperitoneal injection of analgin (1000 mg/kg), antipurine (400 mg/kg), amidopyrine (100 mg/kg) 3 hours before the irradiation of mice in a dose of 800 R led to survival of 30 to 45% of the animals (against 12.5% in control) and to increase in the average duration of life of the animals that perished. 80-95% of mice survived the period of "intestinal deaths" (the 7th day after the irradiation) after combined prophylactic use of purasolone derivatives and cystamine before the irradiation of these animals in a dose of 1050 R. The radioprotective effect of pyrasolone derivatives given in therapeutic doses was less pronounced.
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