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  • Title: Oral contraceptives, serum folate, and hematologic status.
    Author: Paine CJ, Grafton WD, Dickson VL, Eichner ER.
    Journal: JAMA; 1975 Nov 17; 234(7):731-3. PubMed ID: 12277148.
    Abstract:
    The effects of oral contraceptives on serum folate and hematologic levels in 526 women were studied by a new radioassay method and by Lactobacillus casei assay. Serum folate levels were not significantly lower compared with a control group (p more than .1 by L casei assay; p more than .2 by radioassay). Hemoglobin values and iron deficiency anemia were significantly less in the control group (p less than .001). It was concluded that oral contraceptives do not cause folate deficiency anemia.
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