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  • Title: [Effect of cholinesterase inhibitors and reactivators on the blocking action of dicarboxylic acid amino esters on neuromuscular conduction].
    Author: Protas LL, Muske GA, Mndzhoian OL, Danilov AF, Mikhel'son MIa.
    Journal: Farmakol Toksikol; 1975; 38(3):298-303. PubMed ID: 1227902.
    Abstract:
    Inhibition of active cholinesterases in cats with armine or the GT-165 compound (0,0-diethyl-S-/beta-arylmethylamino) ethyl/thiophosphate methylsulphomethylate) potentiases ten- and hundred-fold the blocking action of subecholine and its derivatives on the neuro-muscular condution. The cholinesterase reactivator dipyroxime (2-5 mg/kg) quickly lifts the conduction block, provoked by muscle relaxants of the subecholine type under the cholinesterase inhibition. The subecholine analogue with a single propyl radical at each atom of nitrogen does not display any pressor action and, upon inhibition of cholinesterases, it blocks the neuro-muscular conduction when used in a dose of 0.1-0.2 gamma/kg. The maximal potentiation of the blocking action exerted by subecholine and its analogues is achieved in inhibiting not only pseudocholinesterase but acetylcholinesterase as well.
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