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  • Title: [Open comparative study between the combination clyndamicin/gentamycin and penicillin/gentamycin in septic abortion].
    Author: French AR, Kennion G.
    Journal: Invest Med Int; 1985; 11(4):211-4. PubMed ID: 12280266.
    Abstract:
    Septic abortion is not uncommon in countries where abortion is illegal, and antibiotics are second only to uterine evacuation in the treatment of such cases. Although the combination of penicillin and gentamycin has given excellent results, the high incidence of Bacteroides fragilis and other anerobics in septic abortion prompted a comparison of penicillin and gentamycin with clindamycin and gentamycin at the Hospital Santo Tomas in Panama City, Panama, beginning in May 1984. Among 30 febrile patients with diagnoses of septic abortion, 14 were treated with penicillin/gentamycin and 16 with clindamycin/gentamycin. The penicillin group ranged in age from 17-29 with an average age of 21.9, while the clindamycin group ranged from 18-32 years with an average of 24.3. The average gestational ages were 10.2 weeks for the penicillin group and 10.7 for the clindamycin group. The average body temperature of both groups was 38.9 degrees Celsius. 1 patient had a blood pressure of 80/60 without clinical evidence of shock. The average duration of fever was 43 hours in the penicillin group and 40.6 hours in the clindamycin group. The hospital stay ranged from 3-7 days with an average of 5.4 in the penicillin group and from 3-6 days with an average of 4.2 in the clindamycin group. Patients recovered rapidly after uterine curettage and initiation of antibiotic therapy. Bacteremia was not detected in any patient. Tolerance to the drugs was similar in both groups.
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