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  • Title: [Clinical study of a new protocol on the termination of early pregnancy by administration of dl-15-methyl prostaglandin F2 alpha in combination with testosterone propionate].
    Author: Zhou YF.
    Journal: Shengzhi Yu Biyun; 1988 Aug; 8(3):18-22. PubMed ID: 12281924.
    Abstract:
    Herein are presented the results of termination of early pregnancy by a new protocol using the administration of dl-15-methyl-prostaglandin F2alpha in combination with testosterone propionate in 956 cases studied between January 1984-July 1985, inclusive. Among them, 507 cases were discussed in detail. A comparative study was made between PG vaginal sponge and PG vaginal suppositories. Testosterone propionate 100 mg was given by intramuscular injection daily for 3 days before the day of PG administration. A piece of sponge or a suppository with dl-15-methyl PGF2alpha at random was placed in the posterior fornix of the vagina. An intramuscular injection of 2 mg of the same PG was subsequently given if the product of conception did not pass out after 6 or 12 hours. The success rate varied from 90.91%-100%. There was neither significant difference of the frequency of complete abortion, incomplete abortion, and failure of treatment between the sponge and suppository groups, nor was any significant difference found between the groups of 6 and 12 hour intervals. The authors feel that although the nonsurgical method of using dl-15-methyl PGF2alpha in combination with testosterone propionate cannot take the place of vacuum aspiration for termination of early pregnancy; it is simple, safe, and highly effective with tolerable side effects and without much influence in the reappearance of normal menstruation and fertility. It is especially suitable for those who have a history of recent abortion, cesarean section, uterine abnormality, or pregnancy with lactation amenorrhea, etc. (author's modified)
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