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  • Title: Molecular characteristics of the LH receptor and its role in regulating corpus luteum function.
    Author: Leers-sucheta S, Stormshak F.
    Journal: Adv Contracept Deliv Syst; 1991; 7(2):101-27. PubMed ID: 12284214.
    Abstract:
    Researcher at Oregon State University in Corvallis, Oregon reviewed the literature on molecular characteristics of the receptor of luteinizing hormone (LH) and its role in regulating the function of the corpus luteum. Researchers have been able to make considerable advances recently towards defining the structure of the LH receptor and its role in signal transduction via the stimulated G protein. Several techniques used to determine the molecular structure include direct labeling methods, chemical cross linking, and photoaffinity labeling. The 2 latter methods are cross linked methods. Research shows that the stimulated G protein activates LH which in turn affects luteal cells. Further LH is the leading luteotropin in several mammals including human, monkey, cow, ewe, sow, mare, rat, mouse, hamster, and mink. Nevertheless it seems that neither the gonadotropin not its receptor concentration are limiting factors that trigger luteolysis. Indeed, in the majority of cases, induced down regulation of LH receptors does not prevent basal luteal progesterone secretion. Additional research in the future will provide new data about the LH receptor gene and its regulation. Moreover further research will clarify the biological significance of putative nuclear receptors for LH/human chorionic gonadotropin.
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