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  • Title: A dangerous liaison: tuberculosis and HIV.
    Author: Mckenna N.
    Journal: WorldAIDS; 1992 Sep; (23):3 p.. PubMed ID: 12286182.
    Abstract:
    Tuberculosis (TB) flourishes where there is poverty, malnutrition, overcrowding, and deficient health care. Worldwide, 1 billion 1,722 people are infected with dormant TB. 9-11 million people have active TB predominately in Asia, Africa, and Latin America, and almost 3 million people die of TB annually including 1/2 million of children. WHO estimates that 4.5 million people are coinfected with the human immunodeficiency virus (HIV) and TB in whom active TB can flare up because of weakened immunity. In Uganda, confirmed cases of active TB doubled between 1984 and 1987; and in Zambia TB cases increased from 7000 in 1986 to 17,000 in 1990. Under an assumption of low risk of TB infection and low HIV prevalence scientists have projected that active TB cases in the 15-49 age group will rise by 2/3 by the year 2000. Under a worst case scenario of higher TB infection and higher HIV seroprevalence rates, a 12-fold increase of active TB cases is projected by 2000. Thiacetazone is the main antituberculosis drug in standard chemotherapy. According to WHO data TB has been on the rise in 9 out of 14 European countries with TB infection rates of 10% among HIV-infected people in Spain and Italy. Since 1986 the TB caseload, also has been increasing in the US, and the recent appearance of multi-drug resistant TB (MDR-TB) has raised alarm. MOR-TB almost exclusively infants people with HIV and AIDS with a mortality rate of 80%. The Centers for Disease Control in Atlanta, Georgia, advocates the drastic measure of court-ordered, involuntary detention for treatment to halt its spread.
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