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  • Title: [Effects of steroid contraceptive on serum levels of sex hormone binding globulin in women].
    Author: Zhao XJ, Shao GX, Zhang J, Sang GW.
    Journal: Shengzhi Yu Biyun; 1992 Aug; 12(4):13-7. PubMed ID: 12286664.
    Abstract:
    To investigate the effect of steroids on the level of sex hormone binding globulin (SHBG), 24 women between ages 25 and 35 received one injection of 200 mg norethisterone enanthate (NET-EN). The mean serum SHBG level before the injection was 53.23 mnol/L, with a standard deviation of 23.23 mnol/L. Five days after the injection, the serum SHBG level was reduced to 41.99 +or- 17.06 nmol/L (P.05). 21 days after the injection, the serum SHBG level reached the lowest point of 14.72 +or- 10.01 nmol/L. The SHBG level gradually increased afterwards and did not recover to the premedication level at 84 days with 34.46 +or- 20.39 nmol/L. Two groups of women received oral administration of levonorgestrel (LNG) including one group of 10 women who received a single dose of 6 mg LNG plus 3 mg quinestrol (CEE) and another group of 8 women who received 3 doses of the same regimen as the single-dose group at an interval of 23 days between each dose. The mean premedication SHBG level of the single-dose group was 42.76 +or- 13.89 nmol/L, and it rose to 62.53 +or- 10.9 nmol/L on the seventh day after the administration (p.01). The serum SHBG level peaked at 71.33 +or- 5.77 days after the administration and this high level was sustained until 56 days. For the three doses group, the serum SHBG level prior to medication was 44.94 +or- 15.36 nmol/L. 9 days after the first administration, it reached 83.46 +or- 10.08 nmol/L and peaked at 16 days with 91.74 +or- 2.28 nmol/L. The high serum SHBG level sustained until 30 days after the third administration. The second and third administration of levonorgestrel did not have a significant effect on the SHBG level, as it had already reached a high level. The peak value of LNG blood concentration after the second and third administration was 6 times higher than the peak after the first administration.
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