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  • Title: Some serum biochemical changes associated with chloroform-induced renal tubular necrosis in mice.
    Author: Kruś S, Rosnowska M, Zaleska-Rutczyńska Z.
    Journal: Pol Med Sci Hist Bull (1973); 1975; 15(5-6):525-9. PubMed ID: 1228701.
    Abstract:
    The chloroform--induced renal tubular necrosis is associated with the rise of serum urea, creatinine and potassium. The highest values, observed 24 hours after chloroform administration, are respectively: 75 mg% (norm 32 mg%), 1.75 mg% (norm 0.25 mg%), 6.1 mEq/1 (norm 4.4 mEq/1). They gradually decreased with the progress of renal regeneration. These transient, rather little biochemical deviations justify the good conditions and eventual survival of chloroform-poisoned mice. The contribution of possible glomerular lesions to the disturbed renal function is taken into consideration.
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