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  • Title: [The effect of synthetic derivatives of testosterone on the activity of acid proteinases, DNA-ase and RNA-ase in the liver and serum of female rats].
    Author: Kisliakova ND, Luntovskaia VA.
    Journal: Probl Endokrinol (Mosk); 1975; 21(5):76-81. PubMed ID: 1228755.
    Abstract:
    A study was made of the effect of a 30-day administration of various doses of testosterone-propionate and methyltestosterone to intact female rats given a ration rich in protein on the activity of acid DNA-ase, RNA-ase and proteinases in the liver and the blood serum. The ration itself, rich in proteins, increased the activity of acid RNA in the liver of rats and gave a significant seasonal variations in the activity of RNA-ase and proteinases. Administration of the same doses (1 mg daily) of testosterone-propionate or methyltestosterone produced a different effect on the nuclease metabolism. In the first case there was observed a reduction of the RNA-ase activity, and in the second--of the DNA-ase. Possibly this partially explained a different extent of anabolic properties of these two androgens. An increase in the dose of methyltestosterone to 5 mg, on the contrary, produced activation of RNA-ase in the liver and the blood serum, which could promote the manifestation of catabolic properties.
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