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  • Title: Activation of rabbit brain microsomal (Na+ plus K+)-dependent ATPase by a leukocytic product.
    Author: Riley RS, Rafter GW.
    Journal: Biochim Biophys Acta; 1975 Jan 13; 381(1):120-7. PubMed ID: 122898.
    Abstract:
    The properties of a (Na+ plus K+)-dependent ATPase (ATP phosphohydrolase, EC 3.6.1.3) activator contained in leukocytic extracts was investigated. Intact polymorphonuclear leukocytes release the activator in a time- and temperature-dependent process. It is non-dialyzable through cellophane; inactivated by protease, trypsin, or phenol; contains essential sulfhydryl groups; and is heat and acid labile. Treatment of ATPase with the activator and subsequent removable of the activator from mixtures did not reverse the ATPase activation.
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