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  • Title: FHI study examines N-9 film effect on STDs. Contraceptive update.
    Journal: Netw Res Triangle Park N C; 1997; 17(3):4-5. PubMed ID: 12292394.
    Abstract:
    A 2-year Family Health International (FHI) study concluded that a spermicidal film containing nonoxynol-9 (N-9) is safe, but does not provide any additional protection for women against HIV, gonorrhea, or chlamydia. The research did not test whether N-9 film used alone offers STD protection. N-9 is available in foams, gels, suppositories, and creams. Women who use diaphragms typically apply N-9 cream or jelly to the diaphragm, and some latex condom lubricants also include N-9. The new study involved 1292 sex workers in Cameroon who volunteered at clinics to take part between March 1995 and December 1996. 478 who were provided a contraceptive film containing N-9 and 463 who were provided a placebo film that did not contain a spermicide, completed the study. Volunteer participants who remained at risk of infection were given condoms and urged to use them with every act of intercourse. For the women completing the study, 147,996 acts of sexual intercourse in the group using N-9 film and condoms were compared with 146,942 acts in the group provided with the placebo film and condoms. For every 100 women using N-9 film and condoms for 1 year (100 woman years), 6.7 became infected with HIV, compared with 6.6 HIV infections using the placebo film and condoms. The respective figures for gonorrhea were 33.3 infections for N-9 and condoms and 31.1 for placebo film and condoms per 100 woman years. Chlamydia infection rates were 20.6 for N-9 and condoms and 22.2 for placebo film ad condoms per 100 woman years. A theoretical concern has been whether frequent use of N-9 may increase the risk of STD infections, since frequent use of the chemical may cause sores that could enhance transmission. There were 42.2 lesions peer 100 woman years among women using N-9 and condoms compared with 33.5 lesions among women using the placebo film and condoms.
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