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  • Title: Research efforts focus on male contraception.
    Journal: Contracept Technol Update; 1998 Feb; 19(2):22-3. PubMed ID: 12293104.
    Abstract:
    The US Contraceptive Research and Development Program is collaborating with scientists around the world to develop new approaches to male contraception. The goal is to identify an approach that provides contraceptive efficacy while maintaining libido and potency. A large multicenter trial coordinated by the World Health Organization showed that weekly testosterone enanthate injections successfully suppressed sperm formation, with minimal side effects and full recovery of sperm production after cessation of treatment. Research is focused on combining testosterone esters or other testosterone delivery systems with a progestin such as depo-medroxyprogesterone acetate, levonorgestrel, desogestrel, or cyproterone acetate. Gonadotropin-releasing hormone agonists and antagonists, alone or in combination with testosterone, also appear to be effective in male contraception. The Rockefeller Foundation, in partnership with the Schering AG pharmaceutical company, is funding research in the interruption of epididymal functions. Also explored will be the delivery of drugs to the epididymis to affect the function of the stored potentially fertilizing sperm.
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