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  • Title: Combinations, the key to global immunization.
    Journal: CVI Forum; 1993 Nov; (5):2-6. PubMed ID: 12294217.
    Abstract:
    Although vaccines exist against almost 30 different diseases and work remains ongoing on additional new vaccines, many of the currently existing and used vaccines are far from ideal. The vaccines being used by the World Health Organization's (WHO) Expanded Program on Immunization (EPI) against the common childhood diseases of diphtheria, whooping cough, neonatal tetanus, measles, and tuberculosis are reaching 80% of the world's children and saving an estimated 3 million of them annually from death. However, of the almost 13 million child deaths which occur every year, more than 2 million die from vaccine-preventable diseases. Immunization coverage must be improved. Finding sufficient funds to allow immunization programs to sustain their current level of coverage is already difficult and becoming more difficult due to rising vaccine and vaccine delivery costs, donor fatigue, and competing demands upon health and development resources. A super-vaccine is therefore needed which contains in 1 dose all of the antigens required for lifelong protection against the most life-threatening and disabling diseases. The move toward this goal has begun with the development of combination vaccines. A brief historical overview of the development of combination vaccines is presented, followed by consideration of the advantages of combination vaccines and the Children's Vaccine Initiative (CVI) strategy of building upon the diphtheria-tetanus-pertussis (DTP) vaccine.
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