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  • Title: WHO / UNAIDS hail consensus on cotrimoxazole use for prevention of HIV related infections in Africa.
    Journal: AIDS Wkly; ; ():16-7. PubMed ID: 12295853.
    Abstract:
    This article reports on the recommendation of the WHO/Joint UN Program on AIDS/HIV to promote the use of cotrimoxazole for the prevention of HIV-related infections in Africa. Several arguments have been raised since the recommendation for its use. Controversies lie in its efficacy in treating opportunistic infections despite its use for Pneumocystis carinii pneumonia. Researchers, however, argue that the drug is effective in preventing certain kinds of bacterial pneumonia and diarrheal diseases, as well as certain septicemia. Furthermore, it can also protect the individual against toxoplasmosis and isosporiasis. Another challenge faced in deciding whether to recommend the use of cotrimoxazole is the risk of creating microbial resistance to the drug if it is widely used as a prophylactic. Weighing the use of cotrimoxazole against the two challenges of differing infections and possible resistance in a region like sub-Saharan Africa would still yield to the urgent need of preventing opportunistic infections in people living with AIDS/HIV.
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