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  • Title: Effects of alpha-ketoglutarate on antioxidants and lipid peroxidation products in rats treated with ammonium acetate.
    Author: Velvizhi S, Dakshayani KB, Subramanian P.
    Journal: Nutrition; 2002 Sep; 18(9):747-50. PubMed ID: 12297211.
    Abstract:
    The effects of alpha-ketoglutarate (alpha-KG) on hyperammonemia induced by ammonium acetate were studied biochemically in experimental rats. The levels of circulatory urea and non-protein nitrogen increased significantly in rats treated with ammonium acetate and decreased significantly in rats treated with alpha-KG and ammonium acetate. In liver and kidney tissues, similar patterns of alterations across groups were observed in the levels of thiobarbituric acid-reactive substances and lipid profile variables (free fatty acids, triacylglycerols, phospholipids, and cholesterol). Further, enzymatic (superoxide dismutase, catalase, and glutathione peroxidase) and non-enzymatic (reduced glutathione) antioxidants in both tissues decreased significantly in rats treated with ammonium acetate and increased significantly in rats treated with alpha-KG and ammonium acetate. The biochemical alterations during alpha-KG treatment might have been due to 1) the detoxification of excess ammonia, 2) participation in the non-enzymatic oxidative decarboxylation during hydrogen peroxide decomposition, and 3) enhancement of the proper metabolism of fats that could suppress oxygen radical generation and thus prevent lipid peroxidative damages in rats.
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