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  • Title: [Effect of serine proteinases on the intracellular dynamics of membrane lipids and aggregation of human thrombocytes].
    Author: Mazhul' VM, Chernovets TS, Zaĭtseva EM, Shcherbin DG.
    Journal: Biofizika; 2002; 47(4):653-62. PubMed ID: 12298202.
    Abstract:
    Room temperature tryptophan phosphorescence (RTTP) of human platelets in suspension was studied. The spectral and kinetic parameters of RTTP of thrombocytes were determined. By using the RTTP, the effect of serine proteases: thrombin, trypsin, and alpha-chymotrypsin at low concentrations (0-50 micrograms/ml) on the slow internal dynamics of membrane proteins was studied. It was shown that short-term incubation of platelets with proteases induces changes in the internal dynamics of membrane proteins in situ, and the magnitude of this effect correlates well with the extent of platelet aggregation. The functional role of the changes in the internal dynamics of membrane proteins and their relationship with intracellular signal transduction were discussed.
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