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  • Title: Macrophage cytotoxicity in the mouse immune response against a skin allograft.
    Author: Dimitriu A, Dy M, Thomson N, Hamburger J.
    Journal: J Immunol; 1975 Jan; 114(1 Pt 1):195-9. PubMed ID: 122985.
    Abstract:
    Macrophage-rich peritoneal cell populations from C57BL/6 mice grafted with DBA/2 skin were found to be cytotoxic against 51Cr-labeled target cells from the donor strain. Normal peritoneal macrophages were also rendered cytotoxic by incubation with acellular supernatants of mixed lymphocyte cultures (MLC) between an allograft recipient and a donor mouse. Supernatants alone were not cytotoxic. The macrophage arming factor(s) was found in supernatants when the MLC was performed after more than 6 to 9 days following grafting. In order to produce MAF, sensitized lymphocytes must usually be stimulated in a specific way by donor type cells. The armed macrophage cytotoxicity was, however, not found to be specific in these experiments.
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