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  • Title: Chymopapain chemonucleolysis in lumbar disk disease.
    Author: Wiltse LL, Widell ER, Yuan HA.
    Journal: JAMA; 1975 Feb 03; 231(5):474-9. PubMed ID: 123015.
    Abstract:
    Experience with chymopapain chemonucleolysis in 1,200 cases of lumbar disk disease indicates that it is an effective method of relieving pain resulting from an abnormal intervertebral disk. Complications were few; anaphylaxis occurring immediately after injection was by far the most serious. With the use of a corticosteroid and an antihistamine in preoperative preparation, the incidence of anaphylaxis had dropped, although it still occurs. On long-term follow-up, chemonucleolysis appears to be as good as laminectomy in properly selected cases.
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