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  • Title: Oral contraceptives and thromboembolism.
    Journal: IPPF Med Bull; 1967; 1(5):4. PubMed ID: 12304982.
    Abstract:
    Recent independent studies undertaken in Britain have demonstrated s tatistically for the first time the increased risk of thromboembolic dis ease among women taking oral contraceptives. The Royal College of General Practitioners study suggests that the risk is increased about 6-fold by pregnancy and about 3-fold by oral contraceptives. The Statistical Research Unit of the M.R.C. listed 29 women with deep-vein thrombosis or pulmonary embolism of whom 14 had been taking oral contraceptives. Of 36 controls with other conditions only 3 were using the pill. The Committee on Safety of Drugs study reports 378 deaths in married women aged 15-44 during 1966; in 261 thromboembolic disease was mentioned on the death certificate. Coronary thrombosis was not associated but cerebral thrombosis and pulmonary embolism were possibly related to use of oral contraceptives. Deaths attributable to oral contraceptive use were approximately 3 per 100,000 users per year. In England and Wales the annual death rate for full-term pregnancies is 12 per 100,000 population. Death rate following abortions for unwanted pregnancies is higher. Advantages of oral contraceptives are, for many women, greater than the risks of iatrogenic morbidity or mortality. However, safer contraceptives must be sought as well as means of discovering which women may be at greatest risk from thromboembolism.
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