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  • Title: A clinico-pathological study of lactational amenorrhoea.
    Author: Das SK, Mitra AK.
    Journal: J Obstet Gynaecol India; 1966; 16():156-63. PubMed ID: 12305462.
    Abstract:
    In order to investigate clinico-pathological problems of lactational amenorrhea, a follow-up study was undertaken in 110 women from the date of childbirth up to the end of the first postnatal year. Analysis of the 110 cases showed that in 12 cases (10.9%) regular menstruation commenced just after the puerperium, irrespective of lactation. In the remaining 98 cases, duration of amenorrhea varied from 7 weeks to a little more than 1 year. Even with prolonged lactation varying from 24 weeks to 1 year, menstruation was restored in 89 cases (80.9%) by the end of 24 weeks. Only in 12 cases (10.9%), menstruation failed to resume even at the end of 1 year. Irregularity of cyclical bleeding was more frequent when menstruation reappeared before 24 weeks. Menstruation did reappear earlier in nonlactating than in lactating women. It was determined that ovarian hormones play little part in the phase of repair and restoration of the endometrial structure up to the end of 3 weeks after childbirth. After the puerperium, estrogen activity is restored and well maintained in 96.1% of the cases of lactational amenorrhea. Evidence of ovulation as indicated by secretory endometrium, glycogen activity, and lowering of alkaline phosphatase activity could be demonstrated in 11.8% of cases during lactational amenorrhea. It was found that ovulation is common in cases where menstruation is resumed before 13 weeks. Lactational amenorrhea, especially within this period, should not be considered as a safe period.
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