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  • Title: Lipids and blood coagulation studies in women using steroidal hormones for contraception.
    Author: Hashmi JA, Kazi AB, Kazi A, Ali N.
    Journal: J Pak Med Assoc (1951); 1972 Aug; 22(8):218-25. PubMed ID: 12305803.
    Abstract:
    The experimental group in this study at the Family Planning Clinic, Jinnah Postgraduate Medical Centre in Karachi, Pakistan consisted of 23 women who had been taking Ovral-28 (oral, .5 mg norgestrel, .05 mg ethinyl estradiol) and 27 women who had been receiving Depoprovera (intramuscular injection every 6 months of 300 mg Medroxy Progesterone Acetate). The 26 controls were clinic newcomers seeking contraceptive advice. Venous blood was obtained from each subject, and estimates were made of total cholesterol, triglycerides, prothrombin time, partial thromboplastin time, euglobulin clot lysis time, and plasma fibrinogen. The women were grouped according to therapy and its length (less than 3 months, 4 months-1 year, and more than 1 year). No significant differences were shown through most of the tests. Except for the women who had received Depoprovera for 4 months-1 year, plasma fibrinogen was significantly elevated (p less than .05) in all treated women. The euglobuli CLOTS LYSIS TIME WAS SIGNIFICANTLY LONGER (P .01) IN WOMEN ON Ovral-28 for 4 months-1 year. It had been suggested that the high prevalence of anemia in Pakistani women protects them against thrombotic complications. On the other hand, most treated subjects in this study were nonanemic, while their lipids had no significant increase.
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