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  • Title: Serum sialic acids in the normal menstrual cycle: a possible test for the prediction of ovulation.
    Author: Naguib YA, Darwish NA, Nabil, Shaarawy M, Nagui AR, Thabet S.
    Journal: J Egypt Soc Obstet Gynecol; 1978 Jan; 4(1):37-48. PubMed ID: 12309831.
    Abstract:
    A test for predicting ovulation is described which is based on measurement of serum sialic acids in normal menstrual cycle. In this study of 7 healthy, fertile women, free, bound, and total sialic acids were determined during various menstrual cycle phases. A second experiment was performed on 109 oral contraceptive pill users who were taking combined formulations for less than 1 year, 1-2 years, and 3-5 years. In addition, urinary luteinizing hormone determinations were made throughout the menstrual cycles. Bound and total sialic acids showed significant drops from Day 9-13 of the menstrual cycle, whereas they were at an almost constant level during the remainder of the cycle. Based on luteinizing hormone determinations, this drop was seen to coincide with the preovulatory estrogen peak, and just preceded the luteinizing hormone peak. Pill users, with anovular cycles, did not show such a drop in bound and total sialic acids. Hence, determination of serum sialic acids may be a useful tool for ovulation detection.
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