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  • Title: Injectable contraception.
    Author: International Planned Parenthood Federation IPPF. International Medical Advisory Panel IMAP.
    Journal: IPPF Med Bull; 1980 Dec; 14(6):1-3. PubMed ID: 12310087.
    Abstract:
    The members of the International Planned Parenthood Federation's recently formed Medical Advisory Panel met in London in October 1980 and discussed recent findings relevant to the controversial injectable contraceptive, Depo-Provera. After reviewing the evidence the panel endorsed the continued use of Depo-Provera but recognized that careful long term investigation of all types of contraceptive methods were needed. The specific conclusions reached by the members were 1) the high rate of death associated with pregnancy and illegal abortion in many developing countries, justifies the continued use of Depo-Provera; 2) monkey studies in which 2 out of 16 monkeys treated with Depo-Provera developed endometrial cancer were considered to be statistically insignifant findings; 3) there was no evidence linking the contraceptive with cervical cancer; 4) human studies show no evidence of a relationship between breast cancer and the use of Depo-Provera; 5) the results of beagle studies in which a relationship between Depo-Provera and breast cancer was observed are not applicable to humans since dogs and humans metabolize progestational steroids differently; 6) Depo-Provera may increase the amount and duration of lactation; 7) only a small fraction of the contraceptive is absorbed into the system of infants breast-fed by mothers who take Depo-Provera and follow-up studies in Chile and Mexico failed to detect any adverse effect of Depo-Provera on the infants; 8) the effects on the fetuses of women who received the injection while pregnant is unknown; 9) weight gain is the only known metabolic effect associated with the injection; 10) serious menstrual disorders among Depo-Provera users are rare; 12) the contraceptive does not appear to cause subsequent infertility.
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