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  • Title: Prostaglandins and reproduction.
    Author: El-mahgoub S.
    Journal: Ain Shams Med J; 1972 Jan; 23(1):89-98. PubMed ID: 12310296.
    Abstract:
    This is a review of the literature and a summary of the findings and the clinical studies dealing with the role of PGs (prostaglandins) in the general field of reproduction. The chemical structure of PGs, including the biosynthetic chain, is reviewed briefly. The role PGs play in normal menstruation and dysmenorrheic menstruation, normal pregnancy, labor induction, postconception fertility control, and induced abortion are reviewed, citing the studies involved. Most of the PGs inhibit spontaneous motility of the human myometrium, varying according to the phase of the menstrual cycle. PGs also have an effect on the fallopian tubes, the ovary, and male reproductive organs. PGs, especially PGF, have been identified in human amniotic fluid during spontaneous abortion and labor. In the future, PGs may be used as postconception fertility control agents, even self-administered agents. PGs could influence the process of reproduction by: 1) delaying ovum transport; 2) having an effect on the site of implantation; 3) acting as an abortifacient; and 4) through luteolytic action.
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