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  • Title: [Progressive polyploidy in mouse liver following repeated hepatectomy].
    Author: Faktor VM, Uryvaeva IV.
    Journal: Tsitologiia; 1975 Aug; 17(8):909-16. PubMed ID: 1231096.
    Abstract:
    Mouse liver regeneration after partial hepatectomy results in sharp changes of ploidy classes towards the increase of high ploidy cells and the decrease low ploidy ones. These changes retain during three months. Each following partial hepatectomy (till 3 times) intensifies the hepatocyte polyploidy with appearance of cells with 32--64 ploidy nuclei. The cell polyploidization stimulated by repeated regenerations is similar to that observed in normal postnatal liver growth.
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