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  • Title: [The "pill" and antibiotics: examples of drug interactions of metabolic origin].
    Author: Imbs JL, Welsch M.
    Journal: J Med Strasb; 1982 Jan; 13(1):77-8. PubMed ID: 12311532.
    Abstract:
    The action and effectiveness of most estroprogestational contraceptive agents can be impaired by interference with administration of certain antibiotics which can modify the hepatic estrogen metabolism. Such antibiotics are: 1) rifampicin, which can inactivate the action of ethinyl estradiol; spotting can be present; 2) ampicillin, chloramphenicol, neomycin, nitrofurantoin, sulfamethoxypyridazine, and penicillin; these agents modify the intestinal bacterial flora, thus reducing the effectiveness of contraception; and 3) troleandomycin, which increases hepatic risk.
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