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  • Title: [Effect of consanguinity and endogamy on mortality and fertility in a Spanish population].
    Author: Cereijo AI, Prieto L, Martinez-frias ML.
    Journal: Genet Iber; 1985; 37(3-4):207-19. PubMed ID: 12315168.
    Abstract:
    The effects of inbreeding and endogamy on prenatal mortality and fertility in a Spanish population were analyzed using the data for control newborns registered in the Spanish Collaborative Study of Congenital Malformations (ECEMC). The ECEMC collects information on all newborns with major or minor malformations diagnosed in the first 72 hours of life in participating maternity hospitals. The controls consist of the first subsequent healthy infant of the same sex born in the same hospital. 5794 ECEMC controls born between April 1976-June 1982 were the subjects of the inbreeding and endogamy study. 116 of the 5609 couples who specified the existence or nonexistence of consanguinity were related. Of the remaining couples, 316 of the 2659 or 11.88% who specified the place of origin of the spouses' parents were considered highly endogamous, 165 couples or 6.21% were considered intermediately endogamous, and 65 couples or 2.44% were considered slightly endogamous. Couples were defined as highly endogamous if at least 1 parent of each spouse came from the same village of fewer than 5000 inhabitants. They were considered intermediately endogamous if at least 1 parent of each came from the same village of 5001-10,000 inhabitants, and slightly endogamous if 1 parent of each came from a village of 10,001-15,000 inhabitants. 2113 couples or 79.47% were considered exogamous, with all parents from different villages or villages with more than 15,000 inhabitants. Considering all pregnancies prior to the most recent one, which ended in the birth of a healthy infant in all cases, 7.85% among the inbred couples ended in abortion, compared to 12.26-13.79% for the other 4 groups. 1.57% of pregnancies among the inbred resulted in still births, a higher proportion than among the other groups although not significantly so. Fertility was studied by comparing the number of pregnancies in each family. The inbred had an average of 2.68, significantly higher than the 2.22 of the exogamous, but the difference disappeared when educational status was controlled. Educational level should be controlled in studies of the effects of endogamy and consanguinity, especially with regard to a variable like fertility that is so largely determined by the socioeconomic environment of the couple.
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