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  • Title: Nonsurgical female sterilization with quinacrine pellets: Malaysian experience.
    Author: Arshat H, Ang Eng Suan, Kwa Siew Kim.
    Journal: Malays J Reprod Health; 1987 Dec; 5(2):61-9. PubMed ID: 12315185.
    Abstract:
    The objectives of the study were to evaluate the effectiveness of intrauterine quinacrine pellet application as a method of female sterilization on the basis of 1 year follow-up; and to evaluate the safety, cost, acceptability and ease of administration of this procedure. In this Malaysian study acceptability appeared to be the main problem towards establishing quinacrine insertion as a nonsurgical female sterilization method for contraception. A number of eligible clients declined to be included in the study when informed that the effectiveness is lower than the other (surgical) method currently available. Also another sterilization study being conducted at the same center was drawing away some of the women seeking permanent contraception. Nevertheless the acceptors included those women with lower education, older age and high parity who therefore would benefit most from this method of sterilization. Due to the small sample size of only 25 subjects it is difficult to draw conclusions at the present moment on the effectiveness and safety of this method of sterilization. Only 1 failure was noted in the insertion period. No pregnancies were reported in the 1-year follow-up period. However, continual follow-up is mandatory considering that pregnancies may occur years later. While menstrual complaints were common, most of the complaints were transient and well tolerated. On the whole morbidity is low. A larger study is needed to test the acceptability of this method.
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