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  • Title: [Steroid contraceptives causing no increase in risk of thromboembolism (case-control study)].
    Author: Ou MQ.
    Journal: Shengzhi Yu Biyun; 1992 Jun; 12(3):18-22. PubMed ID: 12317560.
    Abstract:
    In order to obtain information on the safety of steroids in oral contraceptive I made in China, a case-control study was cond ucted in Shanghai. 62 first-time female patients aged 15-59 who were hospitalized or seen at the emergency room between February 1989 and January 1990 in 7 collaborating hospitals, and who were diagnosed with AMI, cerebral embolism, and thrombosis were studied in comparison with a control group of 181 women. The controls were nonthromboembolism patients at the same age who were hospitalized in the same hospital and at the same time. All women were interviewed about their pregnancies and birth histories, use of steroid contraceptives, and other medicines as well as about diseases and family histories, among other things. Information was also taken from their hospital records. Logistic regression was conducted for single- and multivariate analysis using SPSS/PC+ and Epic software packages. 21% of the cases and the controls used some kind of steroid contraceptives in the past. 92% of the cases had cerebral embolism and were age 30 or over. The result of the analysis showed that the use of steroid contraceptives was not associated with the increased risk of thromboembolism. The important factors associated with thromboembolism were high blood pressure. The duration of the use of steroid contraceptives and the time span from the termination of the use of steroid contraceptives to the occurrence of thromboembolism was not associated with the increase risks of the disease. The authors believed that the findings of the study reflected that fact that none of the cases and the controls smoke or drink. And the most commonly used steroid contraceptives were low dose Oral Pill I suggesting it is a safe method of contraception.
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