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  • Title: Stereostructure of a novel cytotoxic 18-membered macrolactone antibiotic FD-891.
    Author: Eguchi T, Kobayashi K, Uekusa H, Ohashi Y, Mizoue K, Matsushima Y, Kakinuma K.
    Journal: Org Lett; 2002 Oct 03; 4(20):3383-6. PubMed ID: 12323024.
    Abstract:
    The absolute stereochemistry of FD-891, a novel cytotoxic 18-membered macrolactone antibiotic, was determined by a synthetic approach as well as X-ray diffraction of degradative derivatives. The absolute configuration of FD-891 turned out to be as shown above. The stable conformer of FD-891 was also discussed with respect to biological activity by comparison with the structurally related concanamycin A on the bases of molecular mechanics calculations. [structure: see text]
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