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  • Title: Issues in the meta-analysis of cluster randomized trials.
    Author: Donner A, Klar N.
    Journal: Stat Med; 2002 Oct 15; 21(19):2971-80. PubMed ID: 12325113.
    Abstract:
    Meta-analyses involving the synthesis of evidence from cluster randomization trials are being increasingly reported. These analyses raise challenging methodologic issues beyond those raised by meta-analyses which include only individually randomized trials. In this paper we review and comment on a selected number of these issues, including problems of study heterogeneity, difficulties in estimating design effects from individual trials and the choice of statistical methods.
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