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  • Title: Liver function tests in patients on oral progestogens.
    Author: Engineer AD, Gupta V, Tandon P.
    Journal: J Obstet Gynaecol India; 1968 Apr; 18(2):598-605. PubMed ID: 12331828.
    Abstract:
    145 women (age 11-43 years) attending the family planning clinic and gynecological outpatient department of Queen Mary's Hospital or admitted to the gynecology ward were studied for 16 months from August 1965-October 1966 to assess liver function under 2 steroid preparations: Gynovlar--3 mg norethisterone acetate. .05 mg ethinyl estradiol--for contraception, and Noracyclin--5 mg Lynestrenol, .15 mg mestranol--for gynecologic symptoms. Liver function was tested by serum bilirubin, serum alkaline phosphatase, cephalin cholesterol flocculation test, and zinc sulphide turbidity test. In 123 cases SGOT and SGPT estimations were made by colorimetric method of Reitman and Frankel. Results were analyzed on the basis of 2 diet categories--high protein, low-protein--and 2 sub-categories--vegetarian, nonvegetarian. Serum alkaline phosphatase and zinc sulphide turbidity revealed a significant change in cases of low protein diet. 1 patient in the low protein group had a significant change in cephalin cholesterol flocculation. A rise in SGOT and SGPT was demonstrated after 2 weeks of drug administration but was significant only in patients on low protein diets. Impairment of liver function was reversible in 4 months. Low protein diet "potentiates" hepatotoxicity of steroids. There was a very low continuation rate. A more prolonged follow-up was suggested to discover the pattern of hepatic dysfunction.
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