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  • Title: Effects of metoprolol and propranolol on furosemide-stimulated renin release in healthy subjects.
    Author: Attman PO, Aurell M, Johnsson G.
    Journal: Eur J Clin Pharmacol; 1975 Apr 04; 8(3-4):201-4. PubMed ID: 1233219.
    Abstract:
    The effects of single doses of the beta1-receptor antagonist metoprolol (40 mg orally), propranolol (40 mg orally) and placebo were compared on furosemide-stimulated plasma renin activity (PRA) in seven healthy subjects. In the placebo studies, PRA increased by 0.59+/-0.18 ng x ml-1 x h-1 60 minutes after intravenous administration of 30-60 mg furosemide. After propranolol and metoprolol, the corresponding increases in PRA were significantly less pronounced amounting to 0.16+/-0.06 and 0.24+/-0.08 ng x ml-1 x h-1, respectively. The resting heart rate was reduced to the same extent after the two beta-blockers, which means that the two drugs had been given in equipotent beta1-receptor blocking doses. It is suggested that the release of renin from the kidney may partly be mediated via an adrenergic beta1-receptor.
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