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  • Title: Renal lithium, sodium, potassium and water excretion and plasma renin activity in rats in the cold.
    Author: Smith DF, de Jong W.
    Journal: Pharmakopsychiatr Neuropsychopharmakol; 1975 May; 8(3):132-5. PubMed ID: 1233516.
    Abstract:
    A rise in urine volume and in the urinary excretion of lithium and sodium but not of potassium was observed in rats exposed to a cold environmental temperature (4 degrees C) for 3 hours. The level of plasma renin activity after the clerance test was correlated to the urine volume, but not to the electrolyte composition in the urine. The observed changes in the renal elimination of electrolytes and water corresponded to the effect that a cold environmental temperature has on kidney function in man. The results suggest that renal lithium clearance might be elevated in humans during exposure to cold.
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