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  • Title: Corpus luteum function in lactating women using the Progestasert system.
    Author: Abdalla MI, Ibrahim II, Osman MI, Badraoui MH, Askalani H.
    Journal: Contracept Deliv Syst; 1981 Apr; 2(1):127-32. PubMed ID: 12336864.
    Abstract:
    Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), and progesterone (P) were determined in lactating and menstruating women, 6-8 months after delivery. The subjects were categorized into 3 groups: non-IUD users, copper T-200 (Cu T 200) users, and Progestasert system users. Both types of IUDs were inserted immediately postpartum. When the values of each hormone determined at days M -4 and M -3 were averaged for each subject, remarkable decreases in the grand mean values of FSH, LH, and P were evident in Progestasert users. However, a significant difference was noted between the non-IUD and Progestasert groups for LH only. Considering serum P level as the index of corpus luteum function, the incidence of ovulation, corpus luteum insufficiency and anovulation was 50%, 17%, and 33%, respectively, in the Cu T 200 group; and 17, 33, and 50%, respectively, in the Progestasert group. Similar hormonal determinations were carried out 2 months postpartum in 2 groups of amenorrheic and lactating females fitted with Cu T 200 or Progestasert IUDs immediately after delivery. Results revealed 100% anovulation in the Progestasert group, whereas in the Cu T 200 amenorrheic group, 19, 9, and 72% were ovulating, poor corpus luteum, and anovulating, respectively. These data provide evidence that the Progestasert IUD exerts systemic depressive effect on the hypothalamic-pituitary-ovarian axis in lactating women.
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