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  • Title: Follicular inhibin in human and monkey ovaries.
    Author: Channing CP.
    Journal: Res Reprod; 1984 Jul; 16(3):1-2. PubMed ID: 12339669.
    Abstract:
    This article summarizes current research on follicular inhibin in human and monkey ovaries. Bioassay techniques allow the measurement of inhibin activity in ovarian vein bloom of primates and other species. Rats show an increased level of ovarian vein and follicular fluid inhibin activity on the day of pro-estrus, which declines that afternoon and remains low on the day of estrus coincident with the secondary rise of serum follicle stimulating hormone (FSH). Inhibin activity in the follicular fluid of monkeys, rats, and humans is 100-1000 times that in ovarian veins, suggesting that inhibin is largely retained in the follicle. Inhibin activity is detectable in the ovarian vein blood of humans and monkeys when higher levels of estrogen and gonadotropins are being secreted. Alterations in levels of FSH and letuinizing hormone (LH) are partially explained by alterations in the secretion of inhibin activity in cases of polycystic ovarian disease and use of human menopausal gonadotropin for stimulating follicular growth.
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