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  • Title: Influence of metformin on arginine-induced glucagon secretion in human diabetes.
    Author: Carpentier J, Luyckx AS, Lefebvre PJ.
    Journal: Diabete Metab; 1975 Mar; 1():23-8. PubMed ID: 1234063.
    Abstract:
    The insulin and glucagon responses to arginine infusion were investigated in patients with maturity-onset diabetes under control conditions and during metformin therapy. Metformin did not significantly affect the insulin nor the glucagon response to arginine. These data support the concept that biguanide do not act directly on the islets of Langerhans.
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