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  • Title: [Clinical observations on LRH-A used for contraception by luteolysis in normal women--analysis of 88 cases].
    Author: Lu RK, Chen HY, Liu Y, Zhang L, He YJ, Ge LJ, Yuan XW, Qui XD.
    Journal: Shengzhi Yu Biyun; 1987; 7(1):39-40, 45-7. PubMed ID: 12341309.
    Abstract:
    88 healthy female volunteers, ages 17-42, with regular menstrual cycles entered into the trail with a new superactive stimulatory analos of the LRH-A (D-A1a6-EA10) -LH for contraception by luteolysis. The LRH-A was administered intranasally or intramuscularly (im) on days 6-8 following the LH peak/BBT temperature rise for 1-5 successive cycles. Group 1 consisted of 12 women who were given 1000 mcg LRH-A intranasally for 4 days; group 2 consisted of 18 women who were given a single dose of 200 mcg LRH-A im; group 3 had 34 women who were given 200 mcg im b. i. d. for 1 day; and group 4 had 24 women who were given 200 mcg im g.d. for 3 days. During the treatment cycles, no additional contraceptive was used. Luteolysis was defined as the reduction in plasma progesterone and estradiol levels and the shortening of the luteal phase associated with an infertile cycle. Luteolysis occured in 9 of 12 cycles in group 1 with no shortening of the luteal phase in 3 cycles; in 13 of 18 cycles in group 2 with no shortening of the luteal phase in 5 cycles; in 32 of 34 cycles in group 3 with no decline of progesterone in i cycles; in 115 of 120 cycles in group 4 with 5 pregnancies occurring. The results showed that treatment with LRH-A seemed to be more efficient when applies in twice a day or q.d. for 3-4 successive days as compared with a single dose. No severe side effects were observed durin treatment and apparently normal cycles occurred immediately after withdrawal of treatment. The above data indicate that an adequate dose of LRH-A can provide a fairly good luteolysis result in women at the midluteal phase. However, more extensive study is necesary before a long-term application of LRH-A for contraception by luteolysis can be considered practical.
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