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  • Title: [Comparative study on the clinical effects and endometrial findings of IUD].
    Author: Chao CK.
    Journal: Toho Igakkai Zasshi; 1988 Mar; 34(6):550-60. PubMed ID: 12343145.
    Abstract:
    Clinical effects of IUD and its related endometrial changes in 418 women were studied. Typical subjects had their IUDs inserted in their mid to late 20s after 3 pregnancies and 2 child births. Major endometrial changes included leukocyte, endometrial hyperplasia, squamous metaplasia, but no malignant changes were noted. Of 418, 327 had CU-medicated IUDs (Group I) and 91 had non-medicated IUDs (Group II). Group I consisted of 259 users of Copper T-200, 35 users of multi load CU-250, 33 users of Nova T-200. Group II consisted of 54 users of Spira-ring and 37 users of Lippes loop. There was no significant difference between the 2 groups in duration of IUD use. 1/3 of all subjects had their IUDs removed within a year. 80% of CU-medicated IUDs were removed in 1 to 3 years. 20% of both groups removed IUDs because of excessive discharge; 60%, because of genital bleeding; 25%, because of pregnancy. 20% of both groups also complained of pain. The rate of removal due to side-effects was significantly lower in Group I than Group II (p0.001), although the removal due to side-effects took place earlier in Group I than Group II (P0.005). CU-medicated IUDs had lower rate of removal due to pregnancy than non-medicated group (p0.001). 8 cases of all subjects had inflammatory reaction within 2 years of insertion; 27 cases (6.5%), endometrial proliferative activity within 3 years. 7 cases of 259 Copper-T users had squamous metaplasia within two years of insertion. In conclusion, periodic pap smear test should be conducted on IUD users.
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