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  • Title: High-protein diet facilitates growth of children after shigellosis.
    Author: Kabir I.
    Journal: Glimpse; 1992; 14(6):2-3. PubMed ID: 12344718.
    Abstract:
    Health workers randomly assigned 69 2-5 year old children recovering from shigellosis at the hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR,B), to receive either a high-protein diet (150 kcal/kg/day with protein making up 15% of total calories) or a standard control diet (150 kcal/kg/day with protein making up 7.5% of total calories). They received this diet for 21 days. At the end of the study, children in the high-protein diet group were significantly taller and weighed considerably more than those in the standard diet group (p ,01). Moreover, this height spurt was maintained at 3 and 6 months (p .03 and .001, respectively). These children also gained significantly more weight (p .01). Prealbumin and retinol-binding protein increased significantly more among the children in the high-protein diet group than among the controls (p .01), but the mean serum albumin increases were the same. Thus this biochemical parameter suggested that the body used the extra protein to make more of the essential body proteins at a faster rate to make up for the negative nitrogen balance caused by diarrhea during acute shigellosis. Significant increases in somatomedin-C occurred in the high-protein group in comparison to the control group (p .01), indicating that the high-protein diet stimulated growth and effective protein repletion. The children in the high-protein group experienced considerably more of an increase in the fat-free mass than the others (p .01), but this mass was the same for both groups. therefore, the high-protein diet increased more deposition of fat in the muscle tissue than fat tissue. In conclusion, ICDDR,B recommended that physicians use high-protein foods with adequate calories to manage children with shigellosis to help them recover their growth quickly.
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