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  • Title: Changes in drug metabolism with increasing age: 2. phenytoin clearance and protein binding.
    Author: Hayes MJ, Langman MJ, Short AH.
    Journal: Br J Clin Pharmacol; 1975 Feb; 2(1):73-9. PubMed ID: 1234490.
    Abstract:
    1 Comparison of phenytoin clearance showed a marked increase in people over 65 years of age compared with people under 45 years of age. 2 This difference was apparent if phenytoin was given orally or intravenously. 3 Phenytoin clearance correlated inversely with phenytoin binding and plasma albumin, both of which were found to be reduced in the elderly.
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