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  • Title: Fibrinolysis and coagulation markers in seminal plasma before and after vasectomy.
    Author: Van Wersch JW, Ubachs JH, Delaere KP.
    Journal: Fibrinolysis; 1993 Mar; 7(2):135-8. PubMed ID: 12346309.
    Abstract:
    In the Netherlands, physicians at De Wever Hospital in Heerlen compared seminal plasma samples of 80 men before vasectomy with those of 87 men after vasectomy to determine whether coagulation and fibrinolysis markers appear in seminal plasma and, if so, whether vasectomy has an effect on these parameters. They used blood plasma samples from 80 age-matched healthy men to obtain reference values. Even though the median thrombin-antithrombin III complex (TAT-III) values were greater after vasectomy (4.6 vs. 3 mcg/l), they were not significantly different. Yet, they were significantly higher than the median value in blood plasma (4.6 vs. 2.4 mcg/1; p 0.01). The median prothrombin fragment 1.2 levels were essentially the same before and after vasectomy (0.42 vs. 0.55 nmol/l) and within the same range as those in blood plasma (0.66 nmol/l). Postvasectomy median D-dimer levels were much lower than prevasectomy levels (102 vs. 140 mcg/l; p 0.025) and blood plasma levels (199 mcg/l; p 0.001). The median D-dimer/TAT-III ratio was much lower after vasectomy (20 vs. 33.3; p 0.04) and both pre- and postvasectomy ratios were much lower than that of blood plasma (33.3 vs. 70; p 0.001 and 20 vs. 70; p 0.0001, respectively). Pre- and postvasectomy tissue plasminogen activator activities (t-PAact) were essentially the same (211 vs. 186 x 1000 IU/1). Yet, they were much greater than the median t-PAact in blood plasma (by 1.5 x 1000 IU/1; p 0.0001). These findings show that hemostasis products exist in seminal plasma and that vasectomy changes their concentrations. The researchers called for further research to learn the significance of these markers in seminal plasma. Further studies should consider the presence of hemostasis markers to explain earlier identified vasectomy effects.
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