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  • Title: New dimeric macrolide glycosides from the marine sponge Myriastra clavosa.
    Author: Erickson KL, Gustafson KR, Pannell LK, Beutler JA, Boyd MR.
    Journal: J Nat Prod; 2002 Sep; 65(9):1303-6. PubMed ID: 12350152.
    Abstract:
    Clavosolides A-D (1-4), dimeric macrolides incorporating cyclopropyl, tetrahydropyranyl, and glycosidic ring systems, were isolated from the cytotoxic extract of a Philippines collection of the marine sponge Myriastra clavosa. The structures of the clavosolides, which occurred as only trace metabolites, were elucidated through extensive NMR spectroscopic analyses. Clavosolides A (1) and B (2) were recently reported metabolites from M. clavosa, while the unsymmetrical dimers clavosolides C (3) and D (4) had new structures.
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